Protein Details: KCa1.1 (large conductance calcium-activated potassium channels)
Protein ID
ICDB_Pro_1047
Protein Name
KCa1.1 (large conductance calcium-activated potassium channels)
Gene Name
Kcnma1; Kcnma
Organism
Rattus norvegicus (Rat)
Length
1209 amino acids
AlphaFoldDB
AF-Q62976-F1-model_v4.pdb
Function
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems; such as regulation of the contraction of smooth muscle; the tuning of hair cells in the cochlea; regulation of transmitter release; and innate immunity. In smooth muscles; its activation by high level of Ca(2+); caused by ryanodine receptors in the sarcoplasmic reticulum; regulates the membrane potential. In cochlea cells; its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing; phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)
Sequence
PDB Structures
Ligand Binding
Binding Site
440;463;465;986;989;992;994
Disease
Location
DOI ID
10.1161/01.hyp.30.6.1403; 10.1046/j.1432-1327.2000.01076.x; 10.1002/(sici)1098-1136(199904)26:2<166::aid-glia7>3.0.co;2-q; 10.1161/01.res.0000186180.47148.7b; 10.1074/jbc.m008852200; 10.1038/ncomms1871
RefSeq
NP_114016.1